• Ismoilova Ziyoda Aktamovna, Tajiyeva Zebo Bakhodirovna
  Urgen branch of the Tashkent Medical Academy, Republic of Uzbekistan, Urgench

Abstract

Acute kidney injury (AKI) is a complication of COVID-19, and the pathophysiology of AKI in COVID-19 appears to be multifactorial. The pathophysiology of renal dysfunction in patients with COVID-19 has recently been suggested to be secondary to cytokine storm, organ cross-talk, systemic effects and direct tubuloglomerular damage. Damage to tubulointerstitial cells, as a key event in the formation of tubulointerstitial disorders, stimulates the excretion of proinflammatory cytokines and growth factors by these cells and indicates a significant role for the latter as local mediators.

Keywords

Acute kidney injury, cytokines, COVID-19, renal dysfunction, children.

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