• Ismoilova Ziyoda Aktamovna, Tajiyeva Zebo Bakhodirovna
  Urgen branch of the Tashkent Medical Academy, Republic of Uzbekistan, Urgench

Аннотация

Acute kidney injury (AKI) is a complication of COVID-19, and the pathophysiology of AKI in COVID-19 appears to be multifactorial. The pathophysiology of renal dysfunction in patients with COVID-19 has recently been suggested to be secondary to cytokine storm, organ cross-talk, systemic effects and direct tubuloglomerular damage. Damage to tubulointerstitial cells, as a key event in the formation of tubulointerstitial disorders, stimulates the excretion of proinflammatory cytokines and growth factors by these cells and indicates a significant role for the latter as local mediators.

Ключевые слова

Acute kidney injury, cytokines, COVID-19, renal dysfunction, children.

Литература

1. Rowley, A.H. Understanding SARS-CoV-2-related multisystem inflammatory syndrome in children. Nat. Rev. Immunol. 2020, 20, 453–454.

2. Alshami, A.; Roshan, A.; Catapang, M.; Jöbsis, J.J.; Kwok, T.; Polderman, N.; Sibley, J.; Sibley, M.; Mammen, C.; Matsell, D.G.Indications for kidney biopsy in idiopathic childhood nephrotic syndrome. Pediatr. Nephrol. 2017, 32, 1897–1905.

3. Jeyalan, V.; Storrar, J.; Wu, H.H.L.; Ponnusamy, A.; Sinha, S.; Kalra, P.A.; Chinnadurai, R. Native and transplant kidney histopathological manifestations in association with COVID-19 infection: A systematic review. World J. Transpl. 2021, 11, 480–502.

4. Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020 Jun;109(6):1088–95.

5. Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z,et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145(6).

6. CDC COVID-19 Response Team. Coronavirus Disease 2019 in Children- United States, February 12–April 2,2020. MMWR Morb Mortal Wkly Rep. 2020; 69:422-26.