• Амонов М.К.
  Бухарский государственный медицинский институт, Республика Узбекистан, г. Бухара

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Аннотация

Поражение почек является отличительной чертой тяжелого острого респираторного синдрома при COVID-19, приводящего к развитию острого повреждения почек (ОПП) и хронической болезни почек (ХБП) у пациентов с COVID-19. Однако выявление поражения почек у пациентов с COVID-19 может произойти только на поздней стадии на основании текущих клинических анализов крови и мочи. Некоторые исследования указывают на развитие субклинического синдрома острого повреждения почек (субОПП) при COVID-19. Этот синдром характеризуется значительным поражением интерстициальных канальцев без изменения предполагаемой скорости клубочковой фильтрации. Несмотря на сложность механизма (механизмов), лежащего в основе развития субОПП, предполагается изменение механизма белкового эндоцитоза в эпителиальных клетках проксимальных канальцев. В этой статье основное внимание уделяется данным, связанным с суб-ОПП и COVID-19

Ключевые слова

COVID-19; болезнь почек; почечная реабсорбция белка; проксимальный каналец; мегалин; ренин-ангиотензиновая система.

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